The Mercedes-Benz E350 4MATIC was an all wheel drive variant of the W212 Sedan that debuted for the 2010 model year. Based on the W212 E350, the E 350 4MATIC sedan was originally powered by Mercedes' M272 DE35 engine, which was a 288hp naturally aspirated 3.5L V6. This engine was replaced from the 2012 model year by the M276 DE35, which was a new, more efficient V6 that had an output of 302hp. Both engines were paired to a 7 speed automatic transmission that sent power to all four wheels. Production of the W212 Mercedes-Benz E350 4MATIC lasted until 2016.