The V4S was a variant of the Ducati Streetfighter that debuted for the 2020 model year. The Streetfighter V4S was also powered by the Ducati Panigale V4 sport bikes 1103cc Desmosedici Stradale 90° engine. The V4S was not only equipped with quick shift, various riding modes, traction control and cornering ABS as the Streetfighter V4 but was also designed with small additional wings in the side fairings to help producing enough downforce to keep the bike stable at high speeds.