The Mercedes-Benz E 350 was a variant of the W212 Sedan that debuted for the 2010 model year. The E 350 sedan was originally powered by Mercedes' M272 DE35 engine, which was a 288hp naturally aspirated 3.5L V6. This engine was replaced from the 2012 model year by the M276 DE35, which was a new, more efficient V6 that had an output of 302hp. Both engines were paired to a 7 speed automatic transmission that sent power to the rear wheels. Mercedes also offered a four wheel drive version of the E350 that was known as the W212 Mercedes-Benz E350 4MATIC. Production of the W212 Mercedes-Benz E350 lasted until 2016.